NR AYCB
AU Lefrere,J.J.
TI [The risk of prion contamination through the transfusion of cellular products]
OT Le risque de contamination par le prion lors de la transfusion de produits sanguins labiles
QU Transfusion Clinique et Biologique 2007 May; 14(1): 25-34
PT english abstract; journal article
AB Since the publication of observations of variant Creutzfeld-Jacob disease (vCJD) having occurred in the UK due to transfusion of infected packed red cells, the risk of vCJD transmission by blood transfusion is established. In France, no such case has yet been reported, but among the French vCJD cases observed, three individuals, having entered the disease in 2004, are past blood donors. Thus, some individuals transfused in their past are at risk of developing a vCJD. The lack of available assay prevents the diagnosis of the infection in these recipients and the implementation of a specific screening of blood donations. In the UK and in France, several measures to ensure transfusion safety have been applied to reduce the risk of contamination by the variant.
MH Blood Component Transfusion/*adverse effects; Creutzfeldt-Jakob Syndrome/diagnosis/transmission; France; Great Britain; Humans; Prion Diseases/epidemiology/*transmission; Risk Factors; Safety
AD Institut national de la transfusion sanguine, Paris, France. jeanjacqueslefrere@wanadoo.fr
SP französisch
PO Frankreich