NR AYDO
AU Sanjo,N.
TI [Acquired Creutzfeldt-Jakob disease (CJD) - Kuru, iatrogenic CJD, variant CJD]
QU Nippon Rinsho. Japanese Journal of Clinical Medicine 2007 Aug; 65(8): 1438-45
PT english abstract; journal article; review
AB Human prion diseases can be classified as sporadic, hereditary or acquired. The acquired forms are known to be caused by the transmission to human from human or animal, via medical appliances, oral intake or parenteral solutions. Usually, peripheral infection such as oral (Kuru) or parenteral (human pituitary hormones) transmission causes cerebellar degenerative form, and central nervous system infection such as neurosurgical treatment, dura mater grafts or corneal grafts transmission causes clinical features similar to sporadic form of Creutzfeldt-Jakob disease (CJD). The variant CJD (vCJD) is considered to be transmitted bovine spongiform encephalopathy (BSE) to human through dietary exposure. The early clinical features of vCJD are dominated by psychiatric symptoms, and minor number of patients have neurological symptoms from the onset. After about 6 months, there are frank neurological signs, including ataxia, cognitive impairment and involuntary movements.
ZR 27
MH Age of Onset; Animals; Cattle; Corneal Transplantation/adverse effects; Creutzfeldt-Jakob Syndrome/epidemiology/*etiology/physiopathology/*transmission; Dura Mater/transplantation; Humans; *Iatrogenic Disease; Kuru/epidemiology/*etiology/physiopathology/*transmission; Pituitary Hormones/adverse effects
AD Department of Neurology and Neurological Science, Tokyo Medical and Dental University Graduate School of Medicine.
SP japanisch
PO Japan