NR AYDQ
AU Satoh,K.; Shirabe,S.; Eguchi,K.
TI [Clinical typing and diagnosis of sporadic human prion diseases (classic sproadic CJD, MM2-cortical form CJD, MM2-thalamic form CJD)]
QU Nippon Rinsho. Japanese Journal of Clinical Medicine 2007 Aug; 65(8): 1423-32
PT english abstract; journal article; review
AB We described recent knowledge and outline about a diagnosis and clinical typing of sporadic prion disease. Diagnostic procedure and classification based on a pattern of Western blotting of PrPsc, neuropathologic findings, and clinical features. In addition, we described a clinical significance of total tau protein, significance of a diffusion-weighted images of MRI. Analysis of 112 cases of sporadic prion diseases showed 92.3% at positive rate. Sensitivity and specificity were 95.5% and 95.7%, respectively by total tau protein assay of 44 cases of prion diseases.
ZR 27
MH 14-3-3 Proteins/cerebrospinal fluid; Biological Markers/analysis/cerebrospinal fluid; Blotting, Western; Brain/metabolism; Creutzfeldt-Jakob Syndrome/*classification/*diagnosis/pathology; Diffusion Magnetic Resonance Imaging; Electroencephalography; Humans; PrPsc Proteins/analysis; tau Proteins/cerebrospinal fluid
AD First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University.
SP japanisch
PO Japan