NR AYHH
AU Kim,B.H.; Jun,Y.C.; Jin,J.K.; Kim,J.I.; Kim,N.H.; Leibold,E.A.; Connor,J.R.; Choi,E.K.; Carp,R.I.; Kim,Y.S.
TI Alteration of iron regulatory proteins (IRP1 and IRP2) and ferritin in the brains of scrapie-infected mice
QU Neuroscience Letters 2007 Jul 18; 422(3): 158-63
PT journal article; research support, non-u.s. gov't
AB Considerable evidence suggests that oxidative stress may be involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). To investigate the involvement of iron metabolism in TSEs, we examined the expression levels of iron regulatory proteins (IRPs), ferritins, and binding activities of IRPs to iron-responsive element (IRE) in scrapie-infected mice. We found that the IRPs-IRE-binding activities and ferritins were increased in the astrocytes of hippocampus and cerebral cortex in the brains of scrapie-infected mice. These results suggest that alteration of iron metabolism contributes to development of neurodegeneration and that some protective mechanisms against iron-induced oxidative damage may occur during the pathogenesis of TSEs.
MH Animals; Blotting, Western; Brain/*metabolism; Ferritins/genetics/*metabolism; Gene Expression; Gene Expression Profiling; Immunohistochemistry; Iron/metabolism; Iron Regulatory Protein 1/genetics/*metabolism; Iron Regulatory Protein 2/genetics/*metabolism; Male; Mice; Polymerase Chain Reaction; Scrapie/genetics/*metabolism
AD Ilsong Institute of Life Science, Academy of Science, Hallym University, Dongan-gu, Anyang, Kyounggi-do 431-060, South Korea.
SP englisch
PO Irland