NR AYIF
AU Satoh,K.; Shirabe,S.; Tsujino,A.; Eguchi,H.; Motomura,M.; Honda,H.; Tomita,I.; Satoh,A.; Tsujihata,M.; Matsuo,H.; Nakagawa,M.; Eguchi,K.
TI Total tau protein in cerebrospinal fluid and diffusion-weighted MRI as an early diagnostic marker for Creutzfeldt-Jakob disease
QU Dementia and Geriatric Cognitive Disorders 2007; 24(3): 207-12
PT comparative study; journal article
AB BACKGROUND: We have recently begun to doubt the effectiveness of periodic sharp wave complexes observed on electroencephalographs and the detection of 14-3-3 protein in cerebrospinal fluid (CSF) as diagnostic criteria for Creutzfeldt-Jakob disease (CJD). Diffusion-weighted magnetic resonance imaging (DWI) and the detection of total tau (t-tau) protein in CSF may be more sensitive diagnostic criteria. METHODS: Among 44 CJD patients, we selected 21 subjects that suffered from early-stage CJD, which was defined as cases in the 6 weeks following the onset of the disease. The sensitivities of DWI and electroencephalographs, as well as those of t-tau protein, 14-3-3 protein, neuron-specific enolase (NSE), and S-100b protein in CSF were compared as diagnostic markers for early-stage CJD. RESULTS: NSE, S-100b protein, t-tau protein, and 14-3-3 protein were detected in the samples from 57.1, 4.8, 95.2, and 76.2% of the 21 early-stage CJD patients, respectively. Additionally, DWI was used to positively identify 90.5% of these cases. CONCLUSION: We concluded that t-tau protein was the most sensitive of the diagnostic markers for CJD. Moreover, the data in this study showed that detection of t-tau protein combined with DWI identified 98% of the early-stage cases, and these tests should be included as diagnostic criteria for CJD.
MH 14-3-3 Proteins/cerebrospinal fluid; Aged; Aged, 80 and over; Biological Markers; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*diagnosis/pathology; Diffusion Magnetic Resonance Imaging; Electroencephalography; False Negative Reactions; False Positive Reactions; Female; Humans; Male; Middle Aged; Nerve Growth Factors/cerebrospinal fluid; Neuropsychological Tests; Phosphopyruvate Hydratase/cerebrospinal fluid; Prions/cerebrospinal fluid; Reproducibility of Results; Retrospective Studies; S100 Proteins/cerebrospinal fluid; tau Proteins/*cerebrospinal fluid
AD First Department of Internal Medicine, Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan. f1537@cc.nagasaki-u.ac.jp
SP englisch
PO Schweiz