Cell. 1998 Feb 20; 92(4): 573-85

Roland Heynkes 3.4.2026, CC BY-SA-4.0 DE

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Gliederung

NR BACL

AU Takeshi Sakurai, Akira Amemiya, Makoto Ishii, Ichiyo Matsuzaki, Richard M. Chemelli, Hirokazu Tanaka, S.Clay Williams, James A. Richardson, Gerald P. Kozlowski, Shelagh Wilson, Jonathan R.S. Arch, Robin E. Buckingham, Andrea C. Haynes, Steven A. Carr, Roland S. Annan, Dean E. McNulty, Wu-Schyong Liu, Jonathan A. Terrett, Nabil A. Elshourbagy, Derk J. Bergsma, Masashi Yanagisawa

TI Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

QU Cell. 1998 Feb 20; 92(4): 573-85. doi: 10.1016/s0092-8674(00)80949-6

AB The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. We have identified two novel neuropeptides, both derived from the same precursor by proteolytic processing, that bind and activate two closely related (previously) orphan G protein-coupled receptors. These peptides, termed orexin-A and -B, have no significant structural similarities to known families of regulatory peptides. prepro-orexin mRNA and immunoreactive orexin-A are localized in neurons within and around the lateral and posterior hypothalamus in the adult rat brain. When administered centrally to rats, these peptides stimulate food consumption. prepro-orexin mRNA level is up-regulated upon fasting, suggesting a physiological role for the peptides as mediators in the central feedback mechanism that regulates feeding behavior.

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