British Journal of Experimental Pathology 1929 May 10; 10(3): 226-36

Roland Heynkes 13.10.2025, CC BY-SA-4.0 DE

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Gliederung

NR BAAR

AU Alexander Flemming

TI On the antibacterial action of cultures of a Penicillium, with special reference to their use in the isolation of B. influenzæ

QU British Journal of Experimental Pathology 1929 May 10; 10(3): 226-36

AB WHILE working with staphylococcus variants a number of culture-plates were set aside on the laboratory bench and examined from time to time. In the examinations these plates were necessarily exposed to the air and they became contanminated with various micro-organismns. It was noticed that around a large colony of a contaminating mould the staphylococcus colonies became transparent and were obviously undergoing lysis (see Fig. 1). Subcultures of this mould were made and experiments conducted with a view to ascertaining something of the properties of the bacteriolytic substance which had evidently been fornmed in the mould culture and which had diffused into the surrounding medium. It was found that broth in which the mould had been grown at room temperature for one or two weeks had acquired marked inhibitory, bactericidal and bacteriolytic properties to many of the more common pathogenic bacteria.

SP englisch

ZF Alexander Flemming beobachtete auf einer Agarplatte rund um eine große Pilzzellkolonie die Staphylococcus-Kolonien transparent wurden, weil offensichtlich die Bakterien lysiert wurden. Er erkannte, dass der Pilz eine Substanz in das umgebende Medium ausschied, welche die Bakterien tötete. Daraufhin vermehrte er die Pilz-Zellen in flüssigem Medium und konnte zeigen, dass das Medium antibakteriell auf verschiedene pathogene Bakterien-Stämme wirkte, nachdem ein oder zwei Wochen die Pilz-Zellen darin gewachsen waren.

LA baar.pdf