Nature Communications. 2025 Nov 3; Volume 16: Article number: 9698

Roland Heynkes 6.11.2025, CC BY-SA-4.0 DE

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Gliederung

NR BABV

AU Zhuofeng Yu, Declan A. Gray, Jerker Fick, Noel Waters, Richard Lindberg, Roman Grabic, Mats Tysklind, Mutshiene Deogratias Ekwanzala, Hannah-Marie Martiny, Carl-Fredrik Flach, Frank M. Aarestrup & D. G. Joakim Larsson

TI Antibiotic resistance selection and deselection in municipal wastewater from 47 countries

QU Nature Communications. 2025 Nov 3; Volume 16: Article number: 9698. https://doi.org/10.1038/s41467-025-65670-7

AB Wastewaters are plausible arenas for antibiotic resistance evolution and transmission, yet selection for resistance by municipal wastewater has rarely been empirically demonstrated. Here, we experimentally investigate the potential of untreated municipal wastewater from 47 countries to select for antibiotic resistance and explore possible drivers. Using a functional selection assay with 340 mixed Escherichia coli strains, we find that sterile-filtered samples from 14 countries select significantly for resistance to at least one antibiotic class compared to baseline, while the majority select significantly against resistance. Similar results were generated using natural wastewater communities. Additionally, we report a comprehensive characterization of antibiotics and antibacterial biocides in the wastewaters. None of the 22 analyzed antibiotics could be assigned as key drivers for selection in E. coli, whereas e.g. folate pathway antagonists and macrolides often exceed predicted non-selective concentrations for other bacteria by >10-fold. Despite detecting 13 (out of 20 analyzed) organic antibacterial biocides, their potential for co-selection remains unclear. Measured chemical constituents correlate only weakly with observed selection, suggesting complex mixture effects and/or selection by unmeasured compounds. The clear deselection of resistance by most samples indicates that many resistant strains have impaired fitness in wastewaters with limited antibiotic selection pressure.

SP englisch

VT Originaltext

ZF Die Autoren wollten experimentell untersuchen, ob die nicht selten mit Antibiotika belasteten kommunalen Abwässer tatsächlich, wie vermutet, die Entwicklung und Ausbreitung Antibiotika-resistenter Bakterien fördern. Dazu setzten sie ein Gemisch verschiedener Escherichia-coli-Stämme Abwasserproben aus 47 Ländern aus. Abwasserproben aus 14 Ländern selektierten tatsächlich Antibiotika-resistenter Bakterien, während die meisten Abwasserproben die Resistenz-Entwicklung signifikant reduzierten. Anscheinend hatten viele der untersuchten Antibiotika-resistenten Bakterien-Stämme bei geringer Antibiotika-Konzentration einen Selektions-Nachteil.

LA babv.pdf